黃國淵 醫師
現職：
成大醫學院教授兼主治醫師
教育部部定教授
亞太脊椎微創醫學會理事
台灣脊椎微創內視鏡醫學會會員
台灣脊椎外科醫學會暨國際事務委員會委員
中華民國骨科專科醫師暨骨科醫學會會員
台灣醫學會會員
骨質疏鬆症專科醫師
骨質疏鬆症專科醫師
中華民國骨質疏鬆症醫學會會員
國際認證骨質密度臨床專家(Certified Clinical Densitometrist)
台灣再生醫學學會會員
BMC Musculoskeletal Disorders 國際SCI期刊編輯委員
亞太骨科醫學會(APOA Spine section) 終身會員
AO Spine脊椎教育研究機構亞太區會員代表
臨床專長：
脊椎外科
脊椎微創及內視鏡手術
脊椎骨水泥手術
頸椎手術
脊椎側彎
退化性關節炎
關節重建
骨質疏鬆症
一般骨科疾病
學歷：
國立成功大學臨床醫學研究所博士
長庚醫學院醫學系 醫學士
獲獎及榮譽：
1.獲台灣脊椎微創內視鏡醫學會頒發內視鏡手術能力Level 1證書
2.榮獲112學年度PGY住院醫師票選教學優良臨床教師
3.於脊椎外科醫學會112年度會員大會暨第31次學術研討會發表論文，榮獲優秀論文競賽佳作
4.112年參與｢臨床技能石膏訓練工作坊｣擔任講師，獲頒感謝狀。
5.承辦衛福部醫事鑑定案獲選優良鑑定報告，獲成大醫院肯定與鼓勵。
6.111年發表4篇論文於 Cells, Int J Mol Sci, Pharmaceuticals, Bioengineering等四本Impact Factor>5的期刊，榮獲論文獎勵。
7.「Long term survival of ……」獲選成杏基金會2020年臨床醫學組優秀論文獎
8.「Effects of IL-1 beta, IL-20, and BMP-2……」、「Long term survival of ……」、「Optimization of three-level cervical……」等三篇論文榮獲優秀論文，獲頒獎狀
9.黃國淵/林瑞模/許育祥IL-1β, IL-20 or BMP-2 modulates the expression of proinflammatory cytokines, chemotaxis and angiogenesis in herniated intervertebral discs (HIVD) under hypoxia. 榮獲台灣脊椎外科醫學會108年會員大會暨第27次學術研討會獲得優秀論文競賽第三名
10.Kuo-Yuan Huang, Jung-Der Wang, Shang-Chi Lee. Long-term survival of osteoporotic patients with thoracolumbar fractures: Does vertebroplasty improve survival? 榮獲骨質疏鬆症學會106年度會員大會暨學術研討會口頭論文報告競賽第三名
11.榮獲105年度病歷書寫品質優良主治醫師，獲頒獎狀
12.The Differentiation Property and Behavior in Progenitor Cells of Vertebral Endplate, Disc, and Ligamentum flavum.榮獲2016年脊椎外科醫學會優秀論文比賽佳作
13.The correlation between the position of ligamentum flavum degeneration with the severity of calcification and BMP-2. 榮獲骨科醫學會104年度大會優秀論文比賽基礎類別第一名
近年重要論文發表(＊通訊作者或第一作者)：
1. Azril✝, Kuo-Yuan Huang✝, Wen-Lung Liu, Wei-Yu Chen, Chia-Yu Gean, Mehdi Rouhani, Jonathan Hobley, Sai Bhavani Sravan Metla, Yeau-Ren Jeng*, Integrated Nanoindentation-Raman Spectroscopy Reveals Microscale Biomechanical and Molecular Biomarkers of Early Intervertebral Disc Degeneration in a Rat Model. Materials Today Bio., 2025, 35: 102618.
2. Shuang Zou, Sun-Yuan Hsieh, Kuo-Yuan Huang*, Hsin-Hung Chou, Automatic spinal cobb angle measurements from x-ray images using a novel vertebra centroid radiation landmark detection network. Biomed. Signal Proces. 2026, 112:108712.
3. Chong-Sun Khoi, Yen-Ling Chiu, Kuo-Yuan Huang*, Fu-Shun Hsu, Kuan-Lin Kuo, Po-Ming Chow, Chen-Hsun Hsu, Shih-Ming Liao, Yi-Chih Lin, Kao-Yu Chang, Yi-Ju Kao, Shing-Hwa Liu, Wei-Chou Lin, Proteasomal deubiquitinating enzyme usp14/uchl5 inhibitor bap15 suppresses endoplasmic reticulum stress–mediated apoptosis and tumor growth in human chondrosarcoma. Am. J. Cancer Res. 2025, 15(9):4043-4053.
4. Chia-Kung Yen, Hung-Yu Pan, Hsin-I Chang, Ying-Chen Lu, Yeau-Ren Jeng, Cheng-Nan Chen *, Kuo-Yuan Huang * . Low-Frequency Cyclic Stretch Upregulates the Expression of Nuclear Factor Erythroid 2-Related Factor 2 in Human Nucleus Pulposus Cells to Inhibit the Resistin-Induced Interleukin20 Expression. JOR Spine, 2025, 8(1): e70040.
5. Azril✝, Kuo-Yuan Huang✝, Hsin-Yi Liu, Wei-An Liao, Wen-Lung Liu, Jonathan Hobley, Yeau-Ren Jeng * Clinical implications of linking microstructure, spatial biochemical, spatial biomechanical, and radiological features in ligamentum flavum degeneration. JOR Spine, 2024, 7(3): e1365.
6. Wei-Yi Huang †, Yu-Fen Chen †, Kuo-Yuan Huang * The Association between Ambient Air Pollution Exposure and Connective Tissue Sarcoma Risk: A Nested Case-Control Study Using a Nationwide Population-Based Database. Environ. Sci. Pollut. Res., 2024, 31(6): 9078-9090.
7. Kuo-Yuan Huang✝, Yu-Wei Chen, Tzu-Yu Liang, Min-Hua Lai, Jui-Chen Tsai, Yan-Jye Shyong* Evaluation of calcium phosphate-zoledronic acid microparticles as a localized delivery system on bone defect: An in vivo study. J. Drug Deliv. Sci. Technol., 2023, 91: 105260.
8. Li-Wei Cheng, Hsin-Hung Chou, Yu-Xuan Cai, Kuo-Yuan Huang *, Chin-Chiang Hsieh, Po-Lun Chu, I-Szu Cheng and Sun-Yuan Hsieh * Automated Detection of Vertebral Fractures From X-Ray Images: A Novel Machine Learning Model and Survey of the Field. Neurocomputing, 2023, 566: 126946.
9. Yu-Hsiang Hsu, Cheng-Nan Chen, Hsin-I Chang, Hui-Ling Tsai, Yu-Hsien Chang, I-Szu Cheng, Yu-Shiuan Yang and Kuo-Yuan Huang* Manipulation of osteogenic and adipogenic differentiation of human degenerative disc and ligamentum flavum derived progenitor cells using IL-1β, IL-19, and IL-20. Eur Spine J., 2023, 32(10): 3413-3424.
10. Wei-Chou Lin✝, Yen-Lin Chiu✝, Kuan-Lin Kuo✝, Po-Ming Chow, Chen-Hsun Hsu, Shih-Ming Liao, Jun-Ren Dong, Shih-Chen Chang, Shing-Hwa Liu, Tsai-Jung Liu, Fu-Shun-Hsu, Kuo-Chuan Wang, Yi-Chih Lin, Chen-Chih Chang, Kuo-Yuan Huang* Anti-tumor effects of deubiquitinating enzyme inhibitor PR-619 in human chondrosarcoma through reduced cell proliferation and endoplasmic reticulum stress-related apoptosis. Am. J. Cancer Res., 2023, 13(7): 3055-3066.
11. Azril✝, Kuo-Yuan Huang✝, Jonathan Hobley, Mehdi Rouhani, Wen-Lung Liu, Yeau-Ren Jeng* A Methodology to Evaluate Different Histological Preparations of Soft Tissues: Intervertebral Disc Tissues Study. J. Appl. Biomater. Funct. Mater., 2023, 21: 22808000231155634.
12. Azril✝, Kuo-Yuan Huang✝, Jonathan Hobley, Mehdi Rouhani, Wen-Lung Liu, Yeau-Ren Jeng* Correlation of the degenerative stage of a disc with magnetic resonance imaging, chemical content, and biomechanical properties of the nucleus pulposus. J. Biomed. Mater. Res. Part A, 2023, 111(7): 1054-1066.
13. Wong CE, Hu HT, Huang YH, Huang KY* Optimization of Spinal Reconstructions for Thoracolumbar Burst Fractures to Prevent Proximal Junctional Complications: A Finite Element Study. Bioengineering-Basel, 2022, 9(10): 491.
14. Huang KY✝, Chang CH*, Chang YF, Liu JW, Chang JW. Feasibility of Shadowed Image Restoration using the Synthetic Aperture Focusing Technique. Appl. Sci.-Basel, 2022, 12(18):9297.
15. Chen CN, Chang HI, Yen CK, Liu WL and Huang KY* Mechanical stretch induced osteogenesis on human annulus fibrosus cells through upregulation of BMP-2/6 heterodimer and activation of p38 and SMAD1/5/8 signaling pathways. Cells, 2022, 11(16):2600.
16. Chang HI, Chen CN, Huang KY*. Mechanical Stretch-Induced NLRP3 Inflammasome Expression on Human Annulus Fibrosus Cells Modulated by Endoplasmic Reticulum Stress. Int J Mol Sci, 2022, 23(14): 7951.
17. Chang HI, Shao CW, Huang E, Huang KY*. Development of astaxanthin-loaded nanosized liposomal formulation to improve bone health. Pharmaceuticals, 2022, 15(4): 490.
18. Wong CE, Hu HT, Kao LH, Liu CJ, Huang KY* Biomechanical feasibility of semi-rigid stabilization and semi-rigid lumbar interbody fusion: A finite element study. BMC Musculoskelet Disord., 2022, 23(1):10.
19. Wong CE, Hu HT, Tsai CH, Li JL, Hsieh CC, and Huang KY* Comparison of posterior fixation strategies for thoracolumbar burst fracture: A finite element study. J Biomech Eng-Trans ASME, 2021, 143(7):071007-1~8.
20. Wong CE, Hu HT, Hsieh MP, Huang KY*. Optimization of three-level cervical hybrid surgery to prevent adjacent segment disease: A finite element study. Front Bioeng Biotechnol, 2020, 8:154.
21. Hsu YH, Lin RM, Chiu YS, Liu WL and Huang KY*. Effects of IL-1β, IL-20 and BMP-2 on intervertebral disc inflammation under hypoxia. J Clin Med, 2020, 9(1): pii: E140.
22. Huang KY✝, Lee SC, Liu WL and Wang JD* Long term survival of pathological thoracolumbar fractures treated with vertebroplasty: analysis using a nationwide insurance claim database. J Clin Med, 2019, 9(1): pii: E78.
23. Huang KY†, Hsu YH, Chen WY, Tsai HL, Yan JJ, Wang JD, Liu WL and Lin RM. The roles of IL-19 and IL-20 in the inflammation of degenerative lumbar spondylolisthesis. J Inflamm (London), 2018, 15:19
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